Metabolic and cardiovascular responses to chronic intermittent hypoxia and hypercapnia
نویسندگان
چکیده
منابع مشابه
Chronic intermittent hypoxia increases sympathetic responsiveness to hypoxia and hypercapnia.
We sought to determine whether chronic exposure to intermittent hypoxia (CIH) increases sympathetic responsiveness to subsequent chemoreflex stimulation. Sprague-Dawley rats were exposed to 30 days of CIH: exposure chamber %O2 [fractional concentration of chamber O2 (FcO2)] nadir 6.5-7% with return to 21% each minute for 8 h/day during the diurnal sleep period (Exp group). Sham controls (SC gro...
متن کاملChronic intermittent hypoxia alters ventilatory and metabolic responses to acute hypoxia in rats.
We determined the effects of chronic exposure to intermittent hypoxia (CIH) on chemoreflex control of ventilation in conscious animals. Adult male Sprague-Dawley rats were exposed to CIH [nadir oxygen saturation (SpO2), 75%; 15 events/h; 10 h/day] or normoxia (NORM) for 21 days. We assessed the following responses to acute, graded hypoxia before and after exposures: ventilation (V̇e, via baromet...
متن کاملVentilatory and metabolic responses to ambient hypoxia or hypercapnia in rats exposed to CO hypoxia.
We have investigated at ambient temperatures (Tam) of 25 and 5 degrees C the effects of ambient hypoxia (Hxam; fractional inspired O2 = 0.14) and hypercapnia (fractional inspired CO2 = 0.04) on ventilation (V), O2 uptake (VO2), and colonic temperature (Tc) in 12 conscious rats before and after carotid body denervation (CBD). The rats were concomitantly exposed to CO hypoxia (HxCO; fractional in...
متن کاملCARDIOVASCULAR RESPONSES TO HYPERCAPNIA AND VARYING LEVELS OF ARTERIAL pH IN THE ANESTHETIZED CAT
Effects of acute hypercapnia on the cardiovascular system (CYS) were studied in the anesthetized cat. After surgery the animal was exposed to a gas mixture of 12% CO2 and 25% O2 in nitrogen, and hypercapnia with low levels of arterial pH (pHa) was produced for 20 minutes. In the second run the same level of hypercapnia was induced by ventilating the same cat from the above gas mixture but ...
متن کاملAnthony Sica , Deirdre Batson and Steven M . Scharf responsiveness to hypoxia and hypercapnia Chronic intermittent hypoxia increases sympathetic
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.533.4